Search results for " Lung function"

showing 10 items of 30 documents

Impact of gas emboli and hyperbaric treatment on respiratory function of loggerhead sea turtles (Caretta caretta)

2018

We investigated lung function in bycaught sea turtles with and without gas emboli. Hyperbaric O2 treatment significantly improves lung function. Pulmonary function testing may be a useful diagnostic tool to assess fisheries induced trauma.

0106 biological sciences0301 basic medicinePhysiologyRespiratory Medicine and AllergyManagement Monitoring Policy and Lawdecompression sicknesscomparative physiology010603 evolutionary biology01 natural sciencesDecompression sickness03 medical and health sciencesmedicineRespiratory functionRespiratory systemTidal volumeLung functionLungmedicin och allergiNature and Landscape ConservationHyperbaric TreatmentbiologyEcological Modelinglung functionDiving physiology; decompression sickness; lung function; comparative physiologyrespiratory systembiology.organism_classificationmedicine.diseaseDiving physiologyTreatment efficacyrespiratory tract diseases030104 developmental biologySea turtleAnesthesiaResearch Article
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Variants associated with HHIP expression have sex-differential effects on lung function

2021

Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study on lung function to identify genetic effects that differ between males and females. Methods: We tested for interactions between 7,745,864 variants and sex on spirometry-based measures of lung function in UK Biobank (N=303,612), and sought replication in 75,696 independent individuals from the SpiroMeta consortium. Results: Five independent single-nucleotide polymorphisms (SNPs) showed genome-wide significant (P<5x10-8) interactions with sex …

0301 basic medicineSpirometrymedicine.medical_specialtyHHIPMedicine (miscellaneous)Expression ; Genome-wide Interaction Study ; Hhip ; Lung Function ; SexSingle-nucleotide polymorphismBiology3121 Internal medicineGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineExpression ; Genome-wide interaction study ; HHIP ; Lung function ; SexInternal medicineexpressionmedicinesexAlleleEnhancerGeneLung functionLunggenome-wide interaction studymedicine.diagnostic_test1184 Genetics developmental biology physiologylung functionALSPAC/dk/atira/pure/core/keywords/alspacDifferential effects030104 developmental biologyEndocrinologymedicine.anatomical_structure030228 respiratory system3121 General medicine internal medicine and other clinical medicine3111 Biomedicine
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Symptom variability and control in COPD: Advantages of dual bronchodilation therapy

2017

Abstract Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder characterized by usually progressive development of airflow obstruction that is not fully reversible. While most patients will experience symptoms throughout the day or in the morning upon awakening, many patients do not experience their symptoms as constant but report variability in symptoms during the course of the day or over time. Symptom variability adversely affects patients' health status and increases the risk of COPD exacerbations. Methods We examined data from the literature on symptom variability and control in patients with COPD, with focus on the use of inhaled bronchodilator therapy wi…

Aclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Pulmonary and Respiratory MedicineAclidiniumHealth StatusVital CapacityHealth StatuPulmonary Disease Chronic Obstructive0302 clinical medicineForced Expiratory VolumeFormoterol FumarateBronchodilatorBronchodilationFormoterol030212 general & internal medicineAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital CapacityLung functionCOPDbiologyChronic obstructive pulmonary diseaseTropaneLamaBronchodilator AgentsMuscarinic AntagonistTreatment OutcomeInhalationAdministrationCombinationDisease ProgressionDrug Therapy CombinationDrugHumanmedicine.drugAdrenergic beta-2 Receptor AgonistPulmonary and Respiratory MedicineChronic Obstructivemedicine.medical_specialtymedicine.drug_classSymptom variabilitySocio-culturaleMuscarinic AntagonistsSettore MED/10 - Malattie Dell'Apparato RespiratorioDose-Response RelationshipPulmonary Disease03 medical and health sciencesDrug TherapyAdministration InhalationmedicineHumansIntensive care medicineAdrenergic beta-2 Receptor AgonistsBronchodilator AgentDose-Response Relationship Drugbusiness.industryMuscarinic antagonistDual bronchodilator therapymedicine.diseasebiology.organism_classificationLung functionrespiratory tract diseasesAclidinium; Chronic obstructive pulmonary disease; Dual bronchodilator therapy; Formoterol; Lung function; Symptom variability; Administration Inhalation; Adrenergic beta-2 Receptor Agonists; Bronchodilator Agents; Disease Progression; Dose-Response Relationship Drug; Drug Therapy Combination; Forced Expiratory Volume; Formoterol Fumarate; Health Status; Humans; Muscarinic Antagonists; Pulmonary Disease Chronic Obstructive; Quality of Life; Treatment Outcome; Tropanes; Vital Capacity; Pulmonary and Respiratory MedicineDual bronchodilation030228 respiratory systemQuality of LifeFormoterolbusinessTropanesRespiratory Medicine
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Focal airtrapping at expiratory high-resolution CT: comparison with pulmonary function tests

2000

This study was undertaken to determine prevalence, extent, and severity of focal airtrapping at expiratory high-resolution CT, and to compare focal airtrapping with age, gender, pulmonary function tests, and blood gas analysis. Two-hundred seventeen patients with and without pulmonary disease underwent paired inspiratory/expiratory high-resolution CT. Six scan pairs with corresponding scan levels were visually assessed for focal – not diffuse – airtrapping using a four-point scale. Pulmonary function tests and blood gas analysis were available for correlation in all patients (mean interval 5 days). Focal airtrapping with lower lung predominance was observed in 80 % of patients. Twenty-six o…

AdultLung DiseasesMalemedicine.medical_specialtyAdolescentHigh resolutionSeverity of Illness IndexPulmonary function testingHumansMedicineRadiology Nuclear Medicine and imagingLung volumesProspective StudiesAgedNeuroradiologyAged 80 and overLungbusiness.industryRespirationUltrasoundGeneral MedicineNormal lung functionMiddle AgedRespiratory Function TestsLung densitymedicine.anatomical_structureFemaleRadiologyBlood Gas AnalysisArtifactsTomography X-Ray ComputedbusinessEuropean Radiology
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Deep inspiration-induced changes in lung volume decrease with severity of asthma

2007

Summary We have previously reported that the magnitude of deep inspiration (DI)-induced bronchodilation is only slightly reduced in mild asthmatics, compared to healthy subjects. The aim of this study was to evaluate whether increased severity of asthma is associated with impairment in the ability of DI to induce changes in lung volume. Thirty-six consecutive asthmatics recruited from the Pulmonary and the Allergy Outpatient Clinics of the Institute of Respiratory Diseases of the University of Palermo were divided into 3 groups: Intermittent (I), Mild Persistent (MP) and Moderate–Severe (MS), based on GINA guidelines. Single dose methacholine (Mch) bronchoprovocations were performed in the …

AdultMalePulmonary and Respiratory MedicineAllergymedicine.medical_specialtyAdolescentVital CapacityBronchiSettore MED/10 - Malattie Dell'Apparato RespiratorioGastroenterologySeverity of Illness IndexBronchial Provocation TestsDrug Administration ScheduleLung inflationBronchoconstrictor Agents03 medical and health sciencesFEV1/FVC ratio0302 clinical medicineInternal medicineForced Expiratory VolumemedicineOutpatient clinicCorticosteroidsHumansLung volumesAlbuterol030212 general & internal medicineasthma deep inspiration lung functionMethacholine ChlorideAsthmaAgedMethacholinebusiness.industryRespiratory diseaseMiddle Agedmedicine.diseaseAsthma3. Good healthBronchodilator Agents030228 respiratory systemInhalationAnesthesiaSalbutamolMethacholineBronchodilationFemalebusinessmedicine.drugRespiratory Medicine
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Reduced airway responsiveness in non elite runners

2005

Med Sci Sports Exerc. 2005 Dec;37(12):2019-25. Reduced airway responsiveness in nonelite runners. Scichilone N, Morici G, Marchese R, Bonanno A, Profita M, Togias A, Bonsignore MR. SourceInstitute of Medicine and Pneumology, Respiratory Unit; University of Palermo, Italy. n.scichilone@libero.it Abstract PURPOSE: The effects of endurance training on airway responsiveness in nonasthmatic subjects are poorly defined. We hypothesized that airway responsiveness may differ between none-lite endurance athletes and sedentary subjects, and studied healthy, nonelite runners and sedentary controls by single-dose methacholine challenges carried out in the absence of deep inspirations, in that deep insp…

AdultMalemedicine.medical_specialtyRespiratory SystemVital CapacityPhysical Therapy Sports Therapy and RehabilitationSettore MED/10 - Malattie Dell'Apparato RespiratorioSports MedicineBronchial Provocation TestsRunningEndurance trainingasthma exercise lung functionMedicineHumansOrthopedics and Sports MedicineMethacholine Chloridebiologybusiness.industryAthletesAirway Resistancerespiratory systembiology.organism_classificationrespiratory tract diseasesRespiratory Function TestsCase-Control StudiesPhysical therapyPhysical EnduranceFemalebusinessAirway responsivenessInspiratory Capacity
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Influence of Walking as Physiological Training to Improve Respiratory Parameters in the Elderly Population.

2022

Walking as physiological training is reported to be an effective activity in order to beneficially influence and slow the onset of aging in healthy elderly people. However, insufficient evidence exists on how walking influences lung function in seniors. In our study, we aim to evaluate the effect of different types of walking on lung function in healthy seniors. The PubMed, Web of Science, Scopus and EBSCO Essentials databases were searched, while the methodological quality was assessed by the RoB2 tool. A total of seven studies (RCTs) published between 2002–2022 that met the eligibility criteria were analysed in this review. All participants were older adults without any specific associate…

Aparell respiratori MalaltiesHealth Toxicology and MutagenesisEducació física per a persones gransRespiratory Systemwalking; aerobic training; elderly; older adults; spirometry; FVC; FEV<sub>1</sub>; lung functionPublic Health Environmental and Occupational HealthExercise TestHumansWalkingExerciseAgedExercise TherapyInternational journal of environmental research and public health
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Minimal clinically important difference for asthma endpoints: an expert consensus report

2020

Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient's medical management.The aim of the current expert consensus report is to provide a “state-of-the-art” review of the currently available literature evidence about MCID for end-points to monitor asthma control, in order to facilitate optimal disease management and identify unmet needs in the field to guide future research.A series of MCID cut-offs are currently available in literature and validated among populations of asthmatic patients, with most of the evidence focusing on outcomes as patient repo…

Asthma asthma management minimal clinically important difference end-pointsPulmonary and Respiratory Medicinemedicine.medical_specialtyConsensusDelphi TechniqueEndpoint DeterminationBronchoconstrictionMEDLINEDelphi methodSocio-culturaleSettore MED/10 - MALATTIE DELL'APPARATO RESPIRATORIOminimal clinically important difference; asthma; lung function; biomarkersMCID03 medical and health sciences0302 clinical medicinePredictive Value of TestsmedicineHumansAnti-Asthmatic Agents030212 general & internal medicineDisease management (health)Intensive care medicineLungAsthmalcsh:RC705-779business.industryMinimal clinically important differenceminimal clinically important differenceExpert consensusend-pointslcsh:Diseases of the respiratory systemmedicine.diseaseMCID asthmaAsthmaTreatment Outcome030228 respiratory systemPredictive value of testsEndpoint DeterminationInflammation MediatorsSymptom AssessmentbusinessBiomarkersasthma managementEuropean Respiratory Review
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COPD classification methods and informativeness on mortality: Contrasting evidences

2013

Understanding whether the ABCD GOLD classification method is informative with respect to the spirometric classification of severity in predicting mortality of patients with chronic obstructive pulmonary disease (COPD) is subject of debate. The results of a study performed on a sample of the Norwegian population (HUNT2) were recently published. Such data showed the inferiority of ABCD classification in predicting mortality compared to the spirometric classification, which was considered the gold standard up to the 2011 version of GOLD guidelines. This result is not in line with the results of other studies that have shown the equivalence of the two classifications. The new GOLD classificatio…

EpidemiologyCOPD guidelines lung functionPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioChronic obstructive-pulmonary diseaseLung diseasesChronic obstructive; Chronic obstructive-pulmonary disease; Epidemiology; Lung diseases; Pulmonary diseaseChronic obstructive
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Association between greenspace and lung function in Italian children-adolescents

2022

Background: Few studies have examined the impact of urban greenspace exposure on lung function in children-adolescents, and the available evidence is still inconsistent. The aim of the current study was to verify the hypothesis that the effects of greenspace exposure vary with differing levels of lung function of children-adolescents. Methods: Between November 2005 and May 2006, 2150 children-adolescents (age-range: 10-15 years) living in the city of Palermo were enrolled in a cross-sectional survey. Parents were interviewed through a modified version of the Italian Studies on Respiratory Disorders in Children and the Environment (SIDRIA) questionnaire. All children-adolescents performed sp…

GreenneAdolescentParks RecreationalRespiratory Tract DiseasesPublic Health Environmental and Occupational HealthLung functionCross-Sectional StudiesSpirometryGreennessQuantile regressionHumansChildLungChildrenChildren; Greenness; Lung function; Quantile regression
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